June 30: All sessions must be confirmed. Names, titles, affiliations
Bucci – OK (Ray)
Functional Interactions between the Retrosplenial Cortex and the Hippocampal Memory System
Description: The retrosplenial cortex is at the intersection between cortical sensory regions and parahippocampal regions that compose the ‘where’ memory pathway. Indeed, retrosplenial cortex is heavily interconnected with each component of the parahippocampal region (e.g., entorhinal cortex, postrhinal cortex, postsubiculum) as well as the hippocampus proper. Thus, the retrosplenial cortex is well-positioned to contribute to information processing in the hippocampal memory system. Until recently, however, the functional contributions of the retrosplenial cortex have remained largely unknown, as has the importance of the specific connections between retrosplenial cortex and individual parahippocampal regions. The overall goal of session is to bring together investigators who are currently utilizing emerging technologies and sophisticated behavioral paradigms to elucidate the functional interactions between retrosplenial cortex and the hippocampal memory system. In addition to presenting current findings, the interaction and integration of the respective lines of research will facilitate informed development of new ideas and theoretical perspectives. Specific goals are to provide new insight into the nature of information processing in the retrosplenial cortex, to determine how it contributes different phases of learning and memory, and specify when and how retrosplenial cortex interacts with individual components of the parahippocampal-hippocampal network.
Individual presentations: – Need to cut to 3-4 and keep molecular
David Bucci: “Stimulus-stimulus associations in retrosplenial cortex”
Kevin Corcoran: “Molecular and physiological mechanisms of fear extinction in retrosplenial cortex”
Kiriana Cowansage: “Genetic tracking and manipulation of plastic neocortical circuits”
Fred Helmstetter: “Cortical contributions to fear extinction and memory updating”
David Smith: “Retrosplenial Cortical Neurons Encode Important Navigational and Contextual Cues”
Gluck / Yassa – OK (Craig)
Altered Discrimination and Generalization in Mood and Anxiety Disorders
Symposium Organizers: Mark Gluck (Rutgers University-Newark, gluck@pavlov.rutgers.edu) & Mike Yassa (UC Irvine, myassa@uci.edu)
Symposium Abstract. A growing body of evidence suggests that mood and anxiety disorders have an important cognitive component that can be characterized as dysfunctional alterations in discrimination learning which can lead to aberrant generalization when categorizing novel patterns. The neural loci of these alterations are primarily the medial temporal lobe, especially the dentate gyrus, where neurogenesis may be affected by both disease states as well as treatment protocols, and the amygdala, which is involved in emotional behavioral processing. This interdisciplinary symposium will explore this issue from multiple perspectives including clinical neuropsychology, behavioral genetics, functional brain imaging, rodent models, and neurocomputational modeling. Through this session, we seek to identify overlapping and distinct neurobiological vulnerabilities in emotional memory systems across a range of different mood and anxiety disorders, in keeping with the NIMH’s Research Domain Criteria.
Speakers and Talks:
Rene Hen (Columbia), Harnessing hippocampal stem cells to improve pattern separation and decrease overgeneralization.
Cheryl Conrad (Arizona State University), A two-hit animal model of PTSD, chronic stress and fear conditioning: Implications for extinction and fear generalization
Mike Yassa & Stephanie Leal (UC, Irvine), Reducing emotional memory interference and implications for mood disorders
Mark Gluck & Mohammad Herzallah (Rutgers University-Newark), SSRIs impairs generalization in Major Depressive Disorder, while PTSD results in overgeneralization.
Matt Shapiro – Wait a year?
I would like to propose a session for next year: ‘Neural computation by distributed networks,” with Kevin Guise, Sam Mckenzie, Josh Gordon (or student), Jill Leutgeb and Eva Pastalkova (I’m not sure about the last two, but they’re women recording artists and computation minded). I only spoke to Kevin about it….
MPFC-Hippocampal Interactions
During the past 30 years, the neuropsychology of memory has been conceptualized largely in terms of what Norm White called the “central structures” of multiple, dissociable memory systems. At the behavioral and cognitive level, the goal has been to characterize the functional contribution of different brain regions. At the level of neuronal firing correlates, the focus has been to identify thememory code of the central structures, the one computation performed by each type of cells identified by anatomical location, e.g. how grid cell activity patterns in entorhinal cortex is transformed into place codes by dorsal CA1. While this approach has advanced the neuroscience of memory, it has largely ignored the larger neural context within which the central structures operate. That is, how are memory systems “recruited,” i.e. what brain mechanisms select the associations that guide behavior and link memory with action. Most generally, the question is how distributed brain circuits are coordinated so that active representations within local circuits either do or do not guide behavior. Coordinated LFP oscillations, mixed selectivity, and interactions between prefrontal cortex and memory structures suggest new concepts and findings that may help answer these questions. Growing evidence shows that coherent oscillations between PFC and the hippocampus accompany learning and memory, and the structures “take turns” between leading and following during different memory phases (e.g. CA1 leads during context retrieval and mPFC leads during item discrimination). mPFC activity during learning is crucial for subsequent “release from proactive interference” and facilitates reversal learning by speeding the transition between hippocampal journey codes. When all external conditions are identical, “strategies” associated with different memory systems activate distinct but overlapping hippocampal codes. Combining these observations suggest a new working model by which coherent oscillations synchronize distributed neural groups in frontal and temporal lobes and activate “context, rule, and item” information in temporally extended sequences.
Roberto Cabeza – Pulled until next year
I’m very interested in memory reactivation/replay, which is a topic investigated both by cogNeuro/fMRI researchers and behavNeuro/electrophys researchers. Do you think this is a topic that would be interesting to the audience of the Winter conference?
Functional Connectivity/Techniques mega session that might be split in 2:
Session 1: Hippocampus physiology / connectivity (Sheri)
- Laura Colgin
- Gyuri Buszaki
- Ivan Soltez
- Atila Losonczy
- Loren Frank (backup)
Session 2: Optogenetics (methods) and other imaging techniques (Brock)
- Kay Tye (MIT) – ask to organize
- Ed Callaway? (Salk high tech tracing techniques person)
- Idea: Replace a speaker slot with some data blitz?
David Foster
Van der Meer
Cliff Kentros
Menno Witter
Olaf Sporns (Edward Bullmore, Randy McIntosh, Jessica Andrews-Hanna, Peggy St Jacques?, more human functional connectivity people like this: Craig/Brock?)
Joe Ledoux
Bo Li (CSH) another great amygdala circuits person who I see also spoke in 2014
Epigenetics and Memory (folded into another)
- – Marcelo likely won’t make it
- Marcelo Wood
- David Sweat
- Eric Klann
- Peter Rapp
What is a representation – OK (Os)
Is the engram at the circuit, synapse, or molecule?
- John Guzowski
- Kelsie Martin
- Eric Klann
- Sam McKenzie
- Fanselow
- Joe LeDoux
- Brian Wiltgen – can’t make it?
Neurobiology of Exercise – OK (Wendy)
- Michelle Voss (U of Iowa)
- Henriette van Praag (NIH)
- Elizabeth Gould (Princeton)
- Heather Cameron (NIH)
- Kirk Erickson